Back when we used to travel back to PA for Christmas and Summer vacation, absolutely. I could drive the route we used to take in my sleep.
I85 to I77 to I81, left at Hagerstown into Breezewood, turnpike to Bedford, I99 to Altoona, 220 to Ebensburg (I think that's the right route #) and then 422 into the Indiana area.
Big peach water tower - Gaffney SC
Jackson Ferry Shot tower - Near Fort Chiswell, NC
Driving forever in the valley next to a mountain ridge - Pretty much the entire way up I81. Feels like you spend 20 hours in Virginia
Breezewood PA, which has an interesting interstate history all on its own.
I'm sure there's others I've forgotten. When I go up that way now I take a different route that is ever so slightly shorter. That route goes over the New River Gorge bridge, which is another interesting piece of americana.